Journal article
Thiol-reactive star polymers functionalized with short ethoxy-containing moieties exhibit enhanced uptake in acute lymphoblastic leukemia cells
N Bayat, N McOrist, N Ariotti, M Lai, KCS Sia, Y Li, JL Grace, JF Quinn, MR Whittaker, M Kavallaris, TP Davis, RB Lock
International Journal of Nanomedicine | DOVE MEDICAL PRESS LTD | Published : 2019
DOI: 10.2147/IJN.S220326
Abstract
Purpose: Directing nanoparticles to cancer cells without using antibodies is of great interest. Subtle changes to the surface chemistry of nanoparticles can significantly affect their biological fate, including their propensity to associate with different cell populations. For instance, nanoparticles functionalized with thiol-reactive groups can potentially enhance association with cells that over-express cell-surface thiol groups. The potential of such an approach for enhancing drug delivery for childhood acute lymphoblastic leukemia (ALL) cells has not been investigated. Herein, we investigate the impact of thiol-reactive star polymers on the cellular association and the mechanisms of upta..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by the National Health and Medical Research Council of Australia (NHMRC Fellowships APP1059804 and APP1157871 to RBL, and NHMRC Program Grant APP1091261 to MK, TPD and RBL). MK is also supported by funding from Cancer Council NSW Program Grant (PG16-01) and an NHMRC Principal Research Fellowship (APP1119152). MK and TPD are supported by the Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (project number CE140100036). JFQ acknowledges the receipt of a Future Fellowship from the Australian Research Council (FT170100144).